Labetalol hydrochloride injection should be used with caution in patients with impaired hepatic function since metabolism of the drug may be diminished. The usual maintenance dosage of labetalol HCl is between 200 and 400 mg twice daily. Since the half-life of labetalol is 5 to 8 hours, steady-state blood levels in the face of a constant rate of infusion would not be reached during the usual infusion time period. The infusion should be continued until a satisfactory response is obtained and should then be stopped and oral labetalol hydrochloride started. The effective intravenous dose is usually in the range of 50 to 200 mg. A total dose of up to 300 mg may be required in some patients. cost of condyline 10 mg
Labetalol can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Clinical trials also included studies utilizing daily doses up to 2400 mg in more severely hypertensive patients. Taking labetalol can make it harder for you to tell when your blood sugar is low. If you have diabetes, check your blood sugar regularly. HCl per mL of the mixture.
Drinking alcohol can further lower your blood pressure and may increase certain side effects of labetalol. Intravenous labetalol HCl has been shown to be effective in lowering blood pressure and relieving symptoms in patients with pheochromocytoma; higher than usual doses may be required. However, paradoxical hypertensive responses have been reported in a few patients with this tumor; therefore, use caution when administering labetalol HCl to patients with pheochromocytoma. ACCESSING OR USING THIS SITE. As with all drugs with beta-blocking activity, certain advice to patients being treated with labetalol HCl is warranted. While no incident of the abrupt withdrawal phenomenon exacerbation of angina pectoris has been reported with labetalol HCl, dosing with labetalol hydrochloride tablets should not be interrupted or discontinued without a physician's advice.
Some smokers are unsuccessful the first time they try to quit. You may need to stop using this product and try again later. Many people who cannot quit the first time are successful the next time. DOSAGE MUST BE INDIVIDUALIZED. The recommended dose is 100 mg daily whether used alone or added to a diuretic regimen. The rate of infusion of the diluted solution may be adjusted according to the blood pressure response, at the discretion of the physician. To facilitate a desired rate of infusion, the diluted solution can be infused using a controlled administration mechanism, eg, graduated burette or mechanically driven infusion pump.
Patients with severe hypertension may require from 1200 mg to 2400 mg per day, with or without thiazide diuretics. Care should be taken if labetalol is used concomitantly with calcium channel antagonists of the verapamil type. Discuss the risks and benefits with your doctor. The plasma half-life of labetalol following oral administration is about 6 to 8 hours. Steady-state plasma levels of labetalol during repetitive dosing are reached by about the third day of dosing. In patients with decreased hepatic or renal function, the elimination half-life of labetalol is not altered; however, the relative bioavailability in hepatically impaired patients is increased due to decreased “first-pass” metabolism. Lund-Johansen, P. 1984-01-01. "Pharmacology of combined alpha-beta-blockade. II. Haemodynamic effects of labetalol". Drugs.
Ventolin, Proventil metaproterenol Alupent pirbuterol Maxair terbutaline Brethaire, Brethine, Bricanyl and theophylline Elixophyllin, Theo-24, Theochron, Uniphyl. Labetalol HCl Injection is intended for intravenous use in hospitalized patients. DOSAGE MUST BE INDIVIDUALIZED depending upon the severity of hypertension and the response of the patient during dosing. The dosage of labetalol tablets used in the hospital may be increased at 1-day intervals to achieve the desired blood pressure reduction. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your or local waste disposal company. Westfall, David P 2004. The downside to it was extreme fatigue. I actually have to take 50 mg twice a day even though the lowest dose is 100 mg. I have to take 2 half pills per dayThe 100 mg twice per day was too much for me and caused extreme dizziness and I felt almost like I might pass out. Taking a half a pill twice per day morning and evening has caused no other side effects other than being very tired and has been very effective at keeping my blood pressure within normal ranges. Labetalol is in a group of drugs called beta-blockers. Beta-blockers affect the heart and circulation blood flow through arteries and veins. Talk with your doctor about your treatment options. And don't hesitate to get some help from the people you love. They're key members of your team. Friends and family can play a huge role in giving you support while you manage your health. Either of two methods of administration of labetalol HCl injection may be used: a repeated intravenous injections, b slow continuous infusion. This medication can cause false results with certain lab tests of the urine. Tell any doctor who treats you that you are using labetalol. While in the hospital, the dosage of the tablets may be increased at 1 day intervals to achieve the desired blood pressure reduction. This drug is not removed by hemodialysis or peritoneal dialysis; a supplemental dose is not needed. Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately. FDA pregnancy category C. It is not known whether labetalol will harm an unborn baby. Labetalol may cause heart or lung problems in a newborn if the mother takes the medication during pregnancy. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Labetalol HCl blunts the reflex tachycardia produced by nitroglycerin without preventing its hypotensive effect. If labetalol HCl is used with nitroglycerin in patients with angina pectoris, additional antihypertensive effects may occur. Do not skip doses or stop taking labetalol without first talking to your doctor. Stopping suddenly may make your condition worse. truvada
Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life. Many adrenal tumors actually make hormones of their own. This is called a "functioning tumor. Long term labetalol use also has different effects from other beta-blocking drugs. Patients should always be kept in a supine position during the period of IV drug administration. A substantial fall in blood pressure on standing should be expected in these patients. The patient's ability to tolerate an upright position should be established before permitting any ambulation, such as using toilet facilities. Richards; J Tuckman; B N Prichard October 1976. You have two adrenal glands, one on top of each kidney, and you could get a tumor in one or both of them. For subsequent outpatient titration or maintenance dosing see Labetalol Hydrochloride Tablets Product Information DOSAGE AND ADMINISTRATION for additional recommendations. Talk with your doctor about making changes to your lifestyle that may help this medication work better such as stress reduction programs, exercise, and dietary changes. If your tumor makes too much of the stress hormone cortisol, you may pick up some extra pounds or get a puffy face. You may also notice stretch marks around your middle. Both men and women might notice they have weaker bones and muscles, and get bruised easily. You may also have swings in your mood or depression. High blood pressure or high blood sugar is also a possibility. Shiohara T, Kano Y 2007. "Lichen planus and lichenoid dermatoses". In Bolognia JL. Dermatology. St. Louis: Mosby. For subsequent outpatient titration or maintenance dosing, see DOSAGE AND ADMINISTRATION in the labetalol hydrochloride tablets Product Information for additional recommendations. Routine laboratory tests are ordinarily not required before or after IV labetalol HCl. In patients with concomitant illnesses, such as impaired renal function, appropriate tests should be done to monitor these conditions. If you have adrenal cancer, sometimes your tumor begins in the outer layer of your adrenal glands, which your doctor may refer to as the cortex. The disease can also start with a tumor that grows in the middle part, called the medulla. It can happen in one or both of your adrenal glands. ffix.info careprost
To lower your risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. Tell your doctor if your condition does not improve or if it worsens for example, your blood pressure readings remain high or increase. Do not share this medication with others. Gastrointestinal: Mesenteric artery thrombosis, ischemic colitis. This can help you by replacing the nicotine in cigarettes. Im gonna to make another appt. no longer want to be on any pharm. meds. Been taking and much more healther action for my body. to many people dying from all this meds. Food and Drug Administration. WebMD does not endorse any specific product, service or treatment. Biopsy. With a needle, your doctor can take a tiny sample of tissue to test under a microscope to see if you have cancer. Labetalol HCl Injection is prepared for continuous intravenous infusion by diluting the vial contents with commonly used intravenous fluids see below. Consult your doctor before -feeding. Katzung, Bertram G. 2006. Basic and clinical pharmacology. New York: McGraw-Hill Medical. buy zanaflex malta
Hypotension, bradycardia, hypoglycemia, and respiratory depression have been reported in infants of mothers who were treated with labetalol HCl for hypertension during pregnancy. Oral administration of labetalol to rats during late gestation through weaning at doses of two to four times the MRHD caused a decrease in neonatal survival. Start this medication on your quit day. Suck on a lozenge when you feel the urge to smoke. Place the lozenge in your and allow it to slowly dissolve over 20-30 minutes. You may feel a warm, tingling sensation. Try not to swallow the dissolved medication. Do not chew or swallow the lozenge. Men with too much estrogen may notice breast growth, impotence, or loss of sex drive. Women who make too many androgens may have excess body hair or a receding hairline, irregular periods, or a deeper voice. Women past menopause may have spotting. Clinical Pharmacology. 12th ed. San Francisco, CA: McGraw Hill Lange Medical; 2012: 151-168. Angina pectoris has not been reported upon labetalol HCl discontinuation. However, following abrupt cessation of therapy with some beta-blocking agents in patients with coronary artery disease, exacerbations of angina pectoris and, in some cases, myocardial infarction have been reported. Therefore, such patients should be cautioned against interruption of therapy without the physician's advice. Even in the absence of overt angina pectoris, when discontinuation of labetalol hydrochloride injection is planned, the patient should be carefully observed and should be advised to limit physical activity. If angina markedly worsens or acute coronary insufficiency develops, administration of labetalol hydrochloride injection should be reinstituted promptly, at least temporarily, and other measures appropriate for the management of unstable angina should be taken.
IV push over 2 minutes. Jaundice or Hepatic Dysfunction: See WARNINGS. Adrenal cancer is one of those conditions that's hard to spot early. Since the half-life of this drug is 5 to 8 hours, steady-state blood levels in the face of a constant rate of infusion would not be reached during the usual infusion time period; the infusion should be continued until a satisfactory response is obtained and should then be stopped and the oral formulation should be started. IV administration, respectively. Beta 2-agonist activity has been demonstrated in animals with minimal beta 1-agonist ISA activity detected. In animals, at doses greater than those required for alpha- or beta-adrenergic blockade, a membrane stabilizing effect has been demonstrated. The blood pressure should be monitored during and after completion of the infusion or intravenous injection. Rapid or excessive falls in either systolic or diastolic blood pressure during intravenous treatment should be avoided. In patients with excessive systolic hypertension, the decrease in systolic pressure should be used as an indicator of effectiveness in addition to the response of the diastolic pressure. buy indocin medication
Either of two methods of administration of Labetalol hydrochloride injection may be used: a repeated intravenous injection, or b slow continuous infusion. The best dose for you is the dose that decreases the urge to smoke without side effects from too much nicotine. Your dose will need to be adjusted to your needs, including history and medical condition. During the first 6 weeks, use 1 lozenge every 1-2 hours at least 9 lozenges a day. The metabolism of labetalol is mainly through conjugation to glucuronide metabolites. These metabolites are present in plasma and are excreted in the urine and, via the bile, into the feces. Approximately 55% to 60% of a dose appears in the urine as conjugates or unchanged labetalol within the first 24 hours of dosing. In patients with latent cardiac insufficiency, continued depression of the myocardium with beta-blocking agents over a period of time can, in some cases, lead to cardiac failure. Most adverse effects are mild, transient and occur early in the course of treatment. The rate of infusion of the diluted solution may be adjusted according to the blood pressure response, at the discretion of the physician. How should I take labetalol Trandate? When you have stopped and you have reached the best dose and schedule for you, continue at that dose. After about 6 weeks, start using fewer lozenges each day as directed in the package or by your doctor until you are no longer and no longer need nicotine replacement. It is important to complete the treatment with this medication 12 weeks. If after the treatment period, you still feel the need to use this medication to prevent you from smoking, talk to your doctor. chloroquine
Major Surgery: The necessity or desirability of withdrawing beta-blocking therapy before major surgery is controversial. Protracted severe hypotension and difficulty in restarting or maintaining a heartbeat have been reported with beta-blockers. Br J Clin Pharmacol. Drummer, O. H. 1984-01-01. "Pharmacology of combined alpha-beta-blockade. I". Drugs. Labetalol Hydrochloride Tablets USP for oral administration contain 100 mg, 200 mg, or 300 mg labetalol HCl. Each tablet also contains the following inactive ingredients: anhydrous lactose, colloidal silicon dioxide, crospovidone, hydroxypropyl methylcellulose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 80, pregelatinized starch, purified water, and titanium dioxide. Labetalol HCl Tablets 100 mg also contain synthetic red iron oxide and synthetic yellow iron oxide. Alternatively, the contents of either two 20 mL vials 40 mL or one 40 mL vial, of labetalol hydrochloride injection are added to 250 mL of a commonly used intravenous fluid. This drug is available at a higher level co-pay. Impaired Hepatic Function: Labetalol HCl tablets should be used with caution in patients with impaired hepatic function since metabolism of the drug may be diminished. Labetalol hydrochloride injection is prepared for continuous intravenous infusion by diluting the vial contents with commonly used intravenous fluids see below. Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Subsequent oral dosing with labetalol HCl tablets should begin when it has been established that the supine diastolic blood pressure has begun to rise. The recommended initial dose is 200 mg, followed in 6 - 12 hours by an additional dose of 200 or 400 mg, depending on the blood pressure response. Hi so yea I have been on this med. for awhile now about 2 years, yes i can say that it has helped with lowering my bp. But the side effects are crazy! Rate of infusion: The rate of infusion of the diluted solution may be adjusted according to the blood pressure response, at the discretion of the physician. If angina markedly worsens or acute coronary insufficiency develops, therapy with Labetalol Hydrochloride Tablets should be reinstituted promptly, at least temporarily, and other measures appropriate for the management of unstable angina should be taken. Patients should be warned against interruption or discontinuation of therapy without the physician's advice. Because coronary artery disease is common and may be unrecognized, it may be prudent not to discontinue therapy with Labetalol Hydrochloride Tablets abruptly in patients being treated for hypertension. Physical exam and medical history. Your doctor will ask you about your health habits and any past problems. ivermectin
IV formulation 58% vs 1% and is often the reason larger doses of the oral formulation cannot be used. When a diuretic is added, an additive antihypertensive effect can be expected. In some cases this may necessitate a labetalol HCl dosage adjustment. As with most antihypertensive drugs, optimal dosages of Labetalol Hydrochloride Tablets are usually lower in patients also receiving a diuretic. Since the half-life of labetalol is 5 to 8 hours, steady-state blood levels in the face of a constant rate of infusion would not be reached during the usual infusion time period. The infusion should be continued until a satisfactory response is obtained and should then be stopped and oral labetalol hydrochloride started. Whether you will be able to withstand a surgery or procedure. There are no adequate and well-controlled studies in pregnant women. Labetalol should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Should side effects principally nausea or dizziness occur with these doses administered twice daily, the same total daily dose administered three times daily may improve tolerability and facilitate further titration. Titration increments should not exceed 200 mg twice daily. If your doctor has directed you to use this medication, remember that he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication not have serious side effects. Serious side effects are more likely if you continue to smoke while using this product. Riva E, Mennini T, Latini R December 1991. Aortic aneurysms that are causing symptoms or enlarging rapidly are considered at risk of rupturing. Repair is usually recommended if either of these factors is present. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
See USP Controlled Room Temperature. Cardiac Failure: Sympathetic stimulation is a vital component supporting circulatory function in congestive heart failure. Beta-blockade carries a potential hazard of further depressing myocardial contractility and precipitating more severe failure. Although beta-blockers should be avoided in overt congestive heart failure, if necessary, labetalol HCl can be used with caution in patients with a history of heart failure who are well compensated. Congestive heart failure has been observed in patients receiving labetalol HCl. Labetalol HCl does not abolish the inotropic action of digitalis on heart muscle. Labetalol HCl combines both selective, competitive, alpha 1-adrenergic blocking and nonselective, competitive, beta-adrenergic blocking activity in a single substance. Overdose symptoms may include slow heart rate, extreme dizziness, or fainting. For subsequent outpatient titration or maintenance dosing, see DOSAGE AND ADMINISTRATION in the labetalol hydrochloride Tablets Product Information for additional recommendations. Labetalol HCl Injection was NOT compatible with 5% Sodium Bicarbonate Injection, USP. cheap allegra online reviews
The amount of alpha to beta blockade depends on whether labetalol is administered orally or IV. Medicines and counseling can help you quit for good. Caution must be observed when reducing severely elevated blood pressure. A number of adverse reactions, including cerebral infarction, optic nerve infarction, angina, and ischemic changes in the electrocardiogram, have been reported with other agents when severely elevated blood pressure was reduced over time courses of several hours to as long as 1 or 2 days. The desired blood pressure lowering should therefore be achieved over as long a period of time as is compatible with the patient's status. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment. The following information is intended to aid in the safe and effective use of this medication. It is not a disclosure of all possible adverse or intended effects. During and immediately following for up to 3 hours labetalol hydrochloride injection, the patient should remain supine. Subsequently, the patient should be advised on how to proceed gradually to become ambulatory and should be observed at the time of first ambulation. This medication is both an alpha blocker and beta blocker. It works by blocking the action of certain natural chemicals in your body such as epinephrine on the heart and blood vessels. This effect lowers the heart rate, blood pressure, and strain on the heart. Chronic Bronchitis and Emphysema: Patients with bronchospastic disease should, in general, not receive beta-blockers. Labetalol Hydrochloride Tablets may be used with caution, however, in patients who do not respond to, or cannot tolerate, other antihypertensive agents. It is prudent, if Labetalol Hydrochloride Tablets are used, to use the smallest effective dose, so that inhibition of endogenous or exogenous beta-agonists is minimized. F. Protect from freezing. The usual maintenance dosage of labetalol HCl is between 200 and 400 mg twice daily. Since the full antihypertensive effect of labetalol HCl is usually seen within the first 1 to 3 hours of the initial dose or dose increment, the assurance of a lack of an exaggerated hypotensive response can be clinically established in the office setting. The antihypertensive effects of continued dosing can be measured at subsequent visits, approximately 12 hours after a dose, to determine whether further titration is necessary. If your doctor has prescribed this medication, read the Patient Information Leaflet if provided by your before you start using this product and each time you get a refill. If you have any questions, consult your doctor or pharmacist. Labetalol HCl produces dose-related falls in blood pressure without reflex tachycardia and without significant reduction in heart rate, presumably through a mixture of its alpha- and beta-blocking effects. Hemodynamic effects are variable, with small, nonsignificant changes in cardiac output seen in some studies but not others, and small decreases in total peripheral resistance. Elevated plasma renins are reduced. Long-term oral dosing studies with labetalol HCl for 18 months in mice and for 2 years in rats showed no evidence of carcinogenesis. Studies with labetalol HCl using dominant lethal assays in rats and mice and exposing microorganisms according to modified Ames tests showed no evidence of mutagenesis. cheapest zebeta order shop otc
The dosage of labetalol hydrochloride Tablets used in the hospital may be increased at 1-day intervals to achieve the desired blood pressure reduction. Subsequent oral dosing with the tablet formulation should begin when it has been established that the supine diastolic blood pressure has begun to rise. Compatibility With Commonly Used Intravenous Fluids: Parenteral drug products should be inspected visually for particulate matter and discoloration before administration whenever solution and container permit. The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. Take this medication by mouth, usually twice a day or as directed by your doctor. You may take this medication with or without food, but it is important to choose one way and take this medication the same way with every dose. Sometimes, by the time you notice symptoms, the tumor may be large. But a lot of treatments, from drugs to surgery, can push back against this cancer. Exacerbation of Ischemic Heart Disease Following Abrupt Withdrawal: Angina pectoris has not been reported upon labetalol HCl discontinuation. However, hypersensitivity to catecholamines has been observed in patients withdrawn from beta-blocker therapy; exacerbation of angina and, in some cases, myocardial infarction have occurred after abrupt discontinuation of such therapy. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day. Slow Continuous Infusion: Labetalol hydrochloride injection is prepared for continuous intravenous infusion by diluting the vial contents with commonly used intravenous fluids see below. Immediately before the injection and at 5 and 10 minutes after injection, supine blood pressure should be measured to evaluate response. Additional injections of 40 or 80 mg can be given at 10-minute intervals until a desired supine blood pressure is achieved or a total of 300 mg of labetalol HCl has been injected. The maximum effect usually occurs within 5 minutes of each injection. Although beta-adrenergic receptor blockade is useful in the treatment of angina and hypertension, there are also situations in which sympathetic stimulation is vital. For example, in patients with severely damaged hearts, adequate ventricular function may depend on sympathetic drive. Beta-adrenergic blockade may worsen A-V block by preventing the necessary facilitating effects of sympathetic activity on conduction. Beta 2-adrenergic blockade results in passive bronchial constriction by interfering with endogenous adrenergic bronchodilator activity in patients subject to bronchospasm, and it may also interfere with exogenous bronchodilators in such patients. Since the half-life of labetalol is 5 to 8 hours, steady-state blood levels in the face of a constant rate of infusion would not be reached during the usual infusion time period. The infusion should be continued until a satisfactory response is obtained and should then be stopped and oral labetalol HCl started see below. The effective intravenous dose is usually in the range of 50 to 200 mg. A total dose of up to 300 mg may be required in some patients. sumatriptan
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This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages. Heart disease runs in my family, predominantly in the women. I am 5"8, 145 lbs, and would consider myself healthy besides the high BP. I was prescribed Labetalol first and just went back to have my Rx changed to a different med. I was on 200mg once a day. I experienced tingling of the scalp and that I could deal with. Due to the alpha 1-receptor blocking activity of labetalol HCl, blood pressure is lowered more in the standing than in the supine position, and symptoms of postural hypotension can occur. During dosing with IV labetalol HCl, the contribution of the postural component should be considered when positioning the patient for treatment, and the patient should not be allowed to move to an erect position unmonitored until his ability to do so is established.
Labetalol is used with or without other medications to treat high blood pressure hypertension. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Alternatively, the contents of either two 20-mL vials 40 mL or one 40-mL vial, of labetalol HCl injection are added to 250 mL of a commonly used intravenous fluid. Safety and effectiveness in pediatric patients have not been established. Labetalol has been shown to cross the placental barrier in humans. Only negligible amounts of the drug crossed the blood-brain barrier in animal studies. Labetalol is approximately 50% protein bound.
Beta 2-agonist activity has been demonstrated in animals with minimal beta 1-agonist ISA activity detected. In animals, at doses greater than those required for alpha- or beta-adrenergic blockade, a membrane-stabilizing effect has been demonstrated. This drug is available at a middle level co-pay. Kidney function declines as you grow older. This medication is removed by the kidneys. Therefore, older adults may be more sensitive to the side effects of this drug, including dizziness and lightheadedness.
This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. Other symptoms of a low blood sugar level, such as dizziness and sweating, are unaffected by this drug. This product may also make it harder to control your blood sugar levels. Check your blood sugar levels regularly as directed by your doctor. Since the full antihypertensive effect of labetalol HCl is usually seen within the first 1 to 3 hours of the initial dose or dose increment, the assurance of a lack of an exaggerated hypotensive response can be clinically established in the office setting. The antihypertensive effects of continued dosing can be measured at subsequent visits, approximately 12 hours after a dose, to determine whether further titration is necessary.